https://www.schuijerslab.com/work daily 1.0 2026-02-26 https://images.squarespace-cdn.com/content/v1/5ec247a767e30b27d646d184/30cbc4d2-fce2-43fe-962a-50a8adda31bd/MonoSat_Model.png Research - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5ec247a767e30b27d646d184/1594726405055-1FSFAWUMUA86ZU3J35FP/Artboard+1%404x-100.jpg Research - Signaling condensates Many cellular processes are organized in localized membraneless compartments called biomolecular condensates. We study the nuclear, cytoplasmic and membrane-associated condensates involved in key signaling pathways such as Wnt, Tgf-β and JAK/STAT. We have developed live-cell imaging techniques to uncover the dynamics and function of these condensates. https://images.squarespace-cdn.com/content/v1/5ec247a767e30b27d646d184/deed1967-f664-49d8-9183-073fb79efb77/EN-Funded+by+the+EU-POS.png Research - This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 897220 https://images.squarespace-cdn.com/content/v1/5ec247a767e30b27d646d184/61767955-0f7b-418a-912d-9200ad76f3e5/OpticalTweezers_2.png Research - Optical-tweezers to explore condensate biology How transcriptional condensates are formed on DNA and how they physically organize the local DNA environment is incompletely understood. We use optical tweezers to directly visualize and quantify how DNA-bound condensates form and determine DNA architecture, and how DNA sequence and chromatin state inform this process. https://images.squarespace-cdn.com/content/v1/5ec247a767e30b27d646d184/1594724090399-GTGMN4RL2WMLHBH6XMAT/UMCU-Website.gif Research - Molecular features underlying condensate formation The capacity to undergo liquid-liquid phase separation (LLPS) is likely to be the driving mechanism for the formation of biomolecular condensates. In order to understand the behavior of signaling condensates we study which molecular features of the terminal signaling factors are important for their propensity to undergo LLPS. Using in vitro droplet formation assays and in vivo perturbation assays we analyze the importance of amino acid side chains, phosphorylation, and backbone flexibility for condensate formation. https://images.squarespace-cdn.com/content/v1/5ec247a767e30b27d646d184/aac2dfbd-8907-491d-a6bd-603563219790/jurian-schuijers.jpg Research https://images.squarespace-cdn.com/content/v1/5ec247a767e30b27d646d184/4dde3c99-7d26-42b8-97c2-c72601803983/Yi-Yun+Lin.jpg Research https://images.squarespace-cdn.com/content/v1/5ec247a767e30b27d646d184/fc4a19f1-b786-41fd-a30c-c21fb1028c3a/CasioFleming_cropped.jpg Research https://images.squarespace-cdn.com/content/v1/5ec247a767e30b27d646d184/bfd697a3-7432-4339-8496-1d00eb092658/Caterina+Manzato+picture.jpg Research - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5ec247a767e30b27d646d184/f1646983-6f24-45d4-b419-be5c93c7fe90/Laurens+Heling.jpg Research - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5ec247a767e30b27d646d184/319417a3-0dbb-48e7-891c-8bf09319c319/Tim_foto.jpg Research https://www.schuijerslab.com/vacancies daily 0.75 2025-05-19 https://www.schuijerslab.com/contact daily 0.75 2021-11-26